2009 | Facharzttitel FMH für Psychiatrie und Psychotherapie |
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2007 | Psychotherapie - Fachtitel in kognitiver Verhaltenstherapie, Universität Basel |
2000 | Doktordiplom der Universität Zürich (Dissertation über Hirntumoren) |
1997-1998 | Postgraduate Kurs in experimenteller Medizin und Biologie an der Universität Zürich |
1996 | Eidgenössisches Staatsexamen an der Universität Basel |
Seit 2008 | Oberärztin Tagesklinik und Ambulatorium, Clienia Psychiatriezentrum Wetzikon |
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2006-2008 | Funktionsoberärztin Tagesklinik, Psychiatrische Privatklinik Sanatorium Kilchberg |
2003-2006 | Assistenzärztin Psychiatrische Privatklinik Sanatorium Kilchberg |
2003 | 4 monatige Praxisassistenz im Kopfwehzentrum Hirslanden Zürich |
2001-2002 | Psychiatrische Universitätsklinik Zürich, gerontopsychiatrische Forschungsstation |
1999-2001 | Psychiatrische Universitätsklinik Zürich, gerontopsychiatrisches Forschungsambulatorium |
1998-1999 | Universitätsspital Zürich, Abt. für klinische Pharmakologie und Toxikologie |
1996-1998 | Universitätsspital Zürich, Abteilung für Neuropathologie |
1. Maddalena A, Papassotiropoulos A, Gonzalez-Agosti C, Signorell A, Hegi Th, Pasch Th,
Nitsch RM, Hock C. Cerebrospinal Fluid Profile of Amyloid β Peptides in Patients with Alzheimer’s
Disease Determined by Protein Biochip Technology.
Neurodegenerative Dis 2004; 1: 231-235
2. Maddalena A, Papassotiropoulos A, Müller-Tillmanns A, Jung HH, Hegi T, Nitsch RM, Hock C.
Biochemical diagnosis of Alzheimer disease by measuring the cerebrospinal fluid ratio of phosphorylated
tau protein to beta-amyloid peptide42.
Arch Neurol. 2003 Sep;60(9):1202-6.
3. Hock C, Konietzko U, Streffer JR, Tracy J, Signorell A, Muller-Tillmanns B, Lemke U, Henke
K, Moritz E, Garcia E, Wollmer MA, Umbricht D, de Quervain DJ, Hofmann M, Maddalena A, Papassotiropoulos
A, Nitsch RM. Antibodies against beta-amyloid slow cognitive decline in Alzheimer's disease.
Neuron. 2003 May 22;38(4):547-54.
4. Hock C, Maddalena A, Raschig A, Müller-Spahn F, Eschweiler G, Hager K, Heuser I, Hampel
H, Müller-Thomsen T, Oertel W, Wienrich M, Signorell A, Gonzalez-Agosti C, Nitsch RM. Treatment
with the selective muscarinic m1 agonist talsaclidine decreases cerebrospinal fluid levels of A beta 42
in patients with Alzheimer's disease.
Amyloid. 2003 Mar;10(1):1-6.
5. Papassotiropoulos A, Streffer JR, Tsolaki M, Schmid S, Thal D, Nicosia F, Iakovidou V, Maddalena
A, Lütjohann D, Ghebremedhin E, Renschler M, Brühl A, Benussi L, Binetti G, Braak H, Nitsch
RM, Hock C. Increased brain beta-amyloid load, phosphorylated tau, and risk of Alzheimer disease
associated with an intronic CYP46 polymorphism.
Arch Neurol. 2003 Jan;60(1):29-35.
6. Wollmer MA, Papassotiropoulos A, Streffer JR, Grimaldi LME, Kapaki E., George P.
Paraskevas GP, Maddalena A, de Quervain D, Bieber C, Umbricht D, Lemke U, Bossardt S,
Degonda N, Henke-Westerholt K, Hegi Th, Jung HH, Pasch Th, Hess K, Hock C, Nitsch RM. Genetic
polymorphisms and cerebrospinal fluid levels of tissue inhibitor of metalloproteinases 1 in sporadic
Alzheimer's disease.
Psychiatr Genet. 2002 Sep;12(3):155-60.
7. Hainfellner JA, Voigtlander T, Strobel T, Mazal PR, Maddalena AS, Aguzzi A, Budka H. Fibroblast
can express glial fibrillary acidic protein (GFAP) in vivo. J. Neuropathol Exp Neurol 2001 May;
60(05):449-61
8. Hock C, Maddalena A, Heuser I, Naber D, Oertel W, von der Kammer H, Wienrich M, Raschig
A, Deng M, Growdon JH, Nitsch RM. Treatment with the selective muscarinic agonist talsaclidine decreases
cerebrospinal fluid levels of total amyloid beta-peptide in patients with Alzheimer's disease.
Ann N Y Acad Sci. 2000;920:285-91.
9. Maddalena AS, Hainfellner JA, Hegi ME, Glatzel M, Aguzzi A. No complementation between
TP53 or RB-1 and v-src in astrocytomas of GFAP-v-src transgenic mice.
Brain Pathol. 1999 Oct;9(4):627-37
10. Theurillat JP, Hainfellner J, Maddalena A, Weissenberger J, Aguzzi A. Early induction of angiogenetic
signals in gliomas of GFAP-v-src transgenic mice.
Am J Pathol. 1999 Feb;154(2):581-90.
11. Rovigatti U, Afanasyeva T, Brandner S, Hainfellner JA, Kiess M, Maddalena A, Malin G, Rulicke
T, Steinbach J, Weissenberger J, Aguzzi A. Transgenic mice as research tools in neurocarcinogenesis.
J Neurovirol. 1998 Apr;4(2):159-74
12. Aguzzi A, Maddalena A, Brandner S, Klein M. Molecular pathogenesis of spongiform encephalopathy.
Pathologica 1997 Oct; 89(5): 481-490. Review. Italian.
Poster-Vorstellungen:
1. Maddalena A, Gonzalez-Agosti C, Lomas L, Nybom P, Pasch T, Nitsch RM, Hock C. Analysis
of Aß species and tau by protein chip technology in CSF of patients with Alzheimer’s disease. Society
for Neuroscience, Annual Meeting 2001, San Diego CA